Efficacy and Safety of a Booster Vaccination with Two Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: Results of a Double-Blind, Randomized, Placebo-Controlled, Phase 3 Trial in Abu Dhabi.

ABSTRACT:

Importance

The protective efficacy of COVID-19 vaccinations has declined over time such that booster doses are required.

Objective

To evaluate the efficacy and adverse events of booster doses of two inactivated COVID-19 vaccines.

Design

This is a double-blind, randomized, placebo-controlled phase 3 trial aiming to evaluate the protective efficacy, safety, and immunogenicity of inactivated SARS-CoV-2 vaccine (Vero cells) after inoculation with booster doses of inactivated COVID-19 vaccine.

Setting

Healthy volunteers were recruited in an earlier phase 3 trial of two doses of inactivated vaccine. The participants in Abu Dhabi maintained the blind state of the trial and received a booster dose of vaccine or placebo at least six months after the primary immunization

SUBMITTER: Al Kaabi N 

PROVIDER: S-EPMC9962595 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature