Structure-Function Studies of Sponge-Derived Compounds on the Cardiac Ca_V3.1 Channel.

ABSTRACT: T-type calcium (Ca_V3) channels are involved in cardiac automaticity, development, and excitation-contraction coupling in normal cardiac myocytes. Their functional role becomes more pronounced in the process of pathological cardiac hypertrophy and heart failure. Currently, no Ca_V3 channel inhibitors are used in clinical settings. To identify novel T-type calcium channel ligands, purpurealidin analogs were electrophysiologically investigated. These compounds are alkaloids produced as secondary metabolites by marine sponges, and they exhibit a broad range of biological activities. In this study, we identified the inhibitory effect of purpurealidin I (1) on the rat Ca_V3.1 channel and conducted structure-activity relationship studies by characterizing the intera

SUBMITTER: Depuydt AS 

PROVIDER: S-EPMC9962600 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature