Survival Factor A (SvfA) Contributes to Aspergillus nidulans Pathogenicity.

ABSTRACT: Survival factor A (SvfA) in Aspergillus nidulans plays multiple roles in growth and developmental processes. It is a candidate for a novel VeA-dependent protein involved in sexual development. VeA is a key developmental regulator in Aspergillus species that can interact with other velvet-family proteins and enter into the nucleus to function as a transcription factor. In yeast and fungi, SvfA-homologous proteins are required for survival under oxidative and cold-stress conditions. To assess the role of SvfA in virulence in A. nidulans, cell wall components, biofilm formation, and protease activity were evaluated in a svfA-gene-deletion or an AfsvfA-overexpressing strain. The svfA-deletion strain showed decreased production of β-1,3-glucan in conidi

SUBMITTER: Lim JY 

PROVIDER: S-EPMC9962611 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature