Inhibition of Succinate Dehydrogenase by Pesticides (SDHIs) and Energy Metabolism.

ABSTRACT: Succinate dehydrogenase (SDH) is one of the enzymes of the tricarboxylic acid cycle (Krebs cycle) and complex II of the mitochondrial respiratory chain. A class of fungicides (SDHIs) targets the complex II reaction in the SDH. A large number of those in use have been shown to inhibit SDH in other phyla, including humans. This raises questions about possible effects on human health and non-target organisms in the environment. The present document will address metabolic consequences in mammals; it is neither a review on SDH nor is it about the toxicology of SDHIs. Most clinically relevant observations are linked to a severe decrease in SDH activity. Here we shall examine the mechanisms for compensating a loss of SDH activity and their possible weaknesses or adverse consequences. It can be ex

SUBMITTER: Bouillaud F 

PROVIDER: S-EPMC9962667 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature