Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool.

ABSTRACT: The Salmonella enterica bacteriophage P22 is one of the most promising models for the development of virus-like particle (VLP) nanocages. It possesses an icosahedral T = 7 capsid, assembled by the combination of two structural proteins: the coat protein (gp5) and the scaffold protein (gp8). The P22 capsid has the remarkable capability of undergoing structural transition into three morphologies with differing diameters and wall-pore sizes. These varied morphologies can be explored for the design of nanoplatforms, such as for the development of cargo internalization strategies. The capsid proteic nature allows for the extensive modification of its structure, enabling the addition of non-native structures to alter the VLP properties or confer them to diverse ends. Various molecules wer

SUBMITTER: Essus VA 

PROVIDER: S-EPMC9962691 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature