Anti-Inflammatory Activity of Compounds Derived from Vitex rotundifolia.

ABSTRACT: The objective of this study is to describe the separation and identification of one new phenolic and 19 known compounds from Vitex rotundifolia. Their structures were determined based on spectroscopic (NMR, CD, and MS) data analysis or Mosher's method, and were compared with those reported in the literature. These isolates were then evaluated for their anti-inflammatory and antioxidant activities based on the inhibition of nitric oxide (NO) and interleukin (IL)-8 production in lipopolysaccharide (LPS)-stimulated cells (RAW264.7 and HT-29) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging abilities, respectively. In the NO assay, compounds 12-14 showed strong inhibition with compounds 10 and 15 displaying significant inhibition. In the IL-8 assay

SUBMITTER: Le D 

PROVIDER: S-EPMC9962727 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature