The Contest of Nanoparticles: Searching for the Most Effective Topical Delivery of Corticosteroids.

ABSTRACT: Owing to their complicated pathophysiology, the treatment of skin diseases necessitates a complex approach. Conventional treatment using topical corticosteroids often results in low effectiveness and the incidence of local or even systemic side effects. Nanoformulation of potent anti-inflammatory drugs has been selected as an optimal strategy for enhanced topical delivery of corticosteroids. In order to assess the efficiency of various nanoformulations, we formulated hydrocortisone (HC) and hydrocortisone-17-butyrate (HCB) into three different systems: lipid nanocapsules (LNC), polymeric nanoparticles (PNP), and ethosomes (ETZ). The systems were characterized using dynamic light scattering for their particle size and uniformity and the morphology of nanoparticles was observed by transmissi

SUBMITTER: Kalvodova A 

PROVIDER: S-EPMC9962773 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature