Indomethacin: Effect of Diffusionless Crystal Growth on Thermal Stability during Long-Term Storage.

ABSTRACT: Differential scanning calorimetry and Raman spectroscopy were used to study the nonisothermal and isothermal crystallization behavior of amorphous indomethacin powders (with particle sizes ranging from 50 to 1000 µm) and their dependence on long-term storage conditions, either 0-100 days stored freely at laboratory ambient temperatures and humidity or placed in a desiccator at 10 °C. Whereas the γ-form polymorph always dominated, the accelerated formation of the α-form was observed in situations of heightened mobility (higher temperature and heating rate), increased amounts of mechanically induced defects, and prolonged free-surface nucleation. A complex crystallization behavior with two separated crystal growth modes (originating from either the mechanical defects or the free surface) was

SUBMITTER: Svoboda R 

PROVIDER: S-EPMC9963031 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature