Facile and dynamic cleavage of every iron-sulfide bond in cuboidal iron-sulfur clusters.

ABSTRACT: Nature employs weak-field metalloclusters to support a wide range of biological processes. The most ubiquitous metalloclusters are the cuboidal Fe-S clusters, which are comprised of Fe sites with locally high-spin electronic configurations. Such configurations enhance rates of ligand exchange and imbue the clusters with a degree of structural plasticity that is increasingly thought to be functionally relevant. Here, we examine this phenomenon using isotope tracing experiments. Specifically, we demonstrate that synthetic [Fe₄S₄] and [MoFe₃S₄] clusters exchange their Fe atoms with Fe²⁺ ions dissolved in solution, a process that involves the reversible cleavage and reformation of every Fe-S bond in the cluster core. This exchange is facil

SUBMITTER: Thompson NB 

PROVIDER: S-EPMC9963086 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature