The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.
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ABSTRACT:
SUBMITTER: Stella GM
PROVIDER: S-EPMC9963101 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.
Stella Giulia M GM Marchiò Caterina C Bari Elia E Ferrarotti Ilaria I Bertuccio Francesco R FR Di Gennaro Antonella A Abbott David Michael DM Putignano Paola P Campo Ilaria I Torre Maria Luisa ML Corsico Angelo G AG
International journal of molecular sciences 20230209 4
MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of ...[more]
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2005-06-01 | GSE2549 | GEO
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