Synthesis and Characterization of a pH- and Temperature-Sensitive Fe₃O₄-SiO₂-Poly(NVCL-co-MAA) Nanocomposite for Controlled Delivery of Doxorubicin Anticancer Drug.

ABSTRACT: This work reports the synthesis, characterization, and in vitro release studies of pH- and temperature-sensitive Fe₃O₄-SiO₂-poly(NVCL-co-MAA) nanocomposite. Fe₃O₄ nanoparticles were prepared by chemical coprecipitation, coated with SiO₂ by the Stöber method, and functionalized with vinyl groups. The copolymer poly(N-vinylcaprolactam-co-methacrylic acid) (poly(NVCL-co-MAA)) was grafted onto the functionalized Fe₃O₄-SiO₂ nanoparticles by free radical polymerization. XRD, FTIR, TGA, VSM, and TEM techniques were performed to characterize the nanocomposite. The release behavior of Doxorubicin (DOX) loaded in the nanocomposite at pH 5.8 and 7.4, and two temperatures, 25 and 37 °C, was studied. Acco

SUBMITTER: Sanchez-Orozco JL 

PROVIDER: S-EPMC9963235 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature