Synthesis and the In Vitro Evaluation of Antitumor Activity of Novel Thiobenzanilides.

ABSTRACT: Cancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Melanoma is a highly aggressive skin tumor with an increasing incidence and poor prognosis in the metastatic stage. Breast cancer still stands as one of the major cancer-associated deaths among women, and diagnosed cases are increasing year after year worldwide. Despite the recent therapeutic advances for this type of cancer, novel drugs and treatment strategies are still urgently needed. In this paper, the synthesis of 18 thiobenzanilide derivatives (17 of them new) is described, and their cytotoxic potential against melanoma cells (A375) and hormone-dependent breast cancer (MCF-7) cells is evaluated using the MTT assay. In the A375

SUBMITTER: Alvaro-Martins MJ 

PROVIDER: S-EPMC9963285 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature