Definition of the contribution of an Osteopontin-producing CD11c⁺ microglial subset to Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most common form of incurable dementia and represents a critical public health issue as the world's population ages. Although microglial dysregulation is a cardinal feature of AD, the extensive heterogeneity of these immunological cells in the brain has impeded our understanding of their contribution to this disease. Here, we identify a pathogenic microglial subset which expresses the CD11c surface marker as the sole producer of Osteopontin (OPN) in the 5XFAD mouse model of AD. OPN production divides Disease-Associated Microglia (DAM) into two functionally distinct subsets, i.e., a protective CD11c⁺OPN^- subset that robustly ingests amyloid β (Aβ) in a noninflammatory fashion and a pathogenic CD11c⁺OPN⁺ subset that

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC9963365 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature