Prostaglandin D₂ Added during the Differentiation of 3T3-L1 Cells Suppresses Adipogenesis via Dysfunction of D-Prostanoid Receptor P1 and P2.

ABSTRACT: We previously reported that the addition of prostaglandin, (PG)D₂, and its chemically stable analog, 11-deoxy-11-methylene-PGD₂ (11d-11m-PGD₂), during the maturation phase of 3T3-L1 cells promotes adipogenesis. In the present study, we aimed to elucidate the effects of the addition of PGD₂ or 11d-11m-PGD₂ to 3T3-L1 cells during the differentiation phase on adipogenesis. We found that both PGD₂ and 11d-11m-PGD₂ suppressed adipogenesis through the downregulation of peroxisome proliferator-activated receptor gamma (PPARγ) expression. However, the latter suppressed adipogenesis more potently than PGD₂, most likely because of its higher resistance to spontaneous transformation into PGJ₂ derivative

SUBMITTER: Nartey MNN 

PROVIDER: S-EPMC9963520 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature