Curvature gradient drives polarized tissue flow in the Drosophila embryo.

ABSTRACT: Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices, which is caused by the activation of actomyosin contractility. This can lead to long-range flows due to tissue viscosity. However, in the absence of cell-intrinsic polarized forces or polarity in forces external to the tissue, these flows must be symmetric and centered around the region of contraction. Polarized tissue flows have been previously demonstrated to arise from the coupling of such contractile flows to points of increased friction or adhesion to external structures. However, we show with experiments and modeling that the onset of polarized tissue flow in early Drosophila morphogenesis occurs independent of adhesion and is instead driven by a geometric coupling of apical actomyosin

SUBMITTER: Gehrels EW 

PROVIDER: S-EPMC9963527 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature