Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells.

ABSTRACT: Background and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: The toxicity of magnolol and/or cisplatin was determined using the MTT technique. The trypan blue method was used to test magnolol and/or cisplatin's effect on MKN-45 cell growth. Crystal violet staining was used to assess the treated cells' tendency for colony formation. The expression of genes linked to apoptosis, cell cycle arrest, and cell migration was examined using the qPCR method. Results: According to MTT data, u

SUBMITTER: Naghashpour M 

PROVIDER: S-EPMC9963572 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature