A DNA Finite-State Machine Based on the Programmable Allosteric Strategy of DNAzyme.

ABSTRACT: Living organisms can produce corresponding functions by responding to external and internal stimuli, and this irritability plays a pivotal role in nature. Inspired by such natural temporal responses, the development and design of nanodevices with the ability to process time-related information could facilitate the development of molecular information processing systems. Here, we proposed a DNA finite-state machine that can dynamically respond to sequential stimuli signals. To build this state machine, a programmable allosteric strategy of DNAzyme was developed. This strategy performs the programmable control of DNAzyme conformation using a reconfigurable DNA hairpin. Based on this strategy, we first implemented a finite-state machine with two states. Through the modular design of the strat

SUBMITTER: Wang J 

PROVIDER: S-EPMC9963683 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature