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Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus.

ABSTRACT: Two unusual polyketide-sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound 1 possessed a rare structure with two aromatic groups. Compounds 1 and 3 showed immunosuppressive activity with IC₅₀ values ranging from 5.516 to 19.953 μM.

SUBMITTER: Dai Q

PROVIDER: S-EPMC9963684 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus.

Dai Quan Q Pang Li-Ting LT Zhang Fa-Lei FL Wang Gang-Qiang GQ Li Xue-Mei XM Liu Ji-Kai JK Feng Tao T

Molecules (Basel, Switzerland) 20230206 4

Two unusual polyketide-sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations ...[more]

PMID: 36838552

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