Molecular Mechanism of Conformational Crossover of Mefenamic Acid Molecules in scCO₂.

ABSTRACT: In this work, we studied conformational equilibria of molecules of mefenamic acid in its diluted solution in scCO₂ under isochoric heating conditions in the temperature range of 140-210 °C along the isochore corresponding to the scCO₂ density of 1.1 of its critical value. This phase diagram range totally covers the region of conformational transitions of molecules of mefenamic acid in its saturated solution in scCO₂. We found that in the considered phase diagram region, the equilibrium of two conformers is realized in this solution. In the temperature range of 140-180 °C, conformer I related to the first, most stable polymorph of mefenamic acid prevails. In the temperature range of 200-210 °C, conformer II, which is related to the second metastable polymorp

SUBMITTER: Oparin RD 

PROVIDER: S-EPMC9963762 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature