Knockout of Purinergic P2Y₆ Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.

ABSTRACT: Nonalcoholic steatohepatitis (NASH) is a disease that progresses from nonalcoholic fatty liver (NAFL) and which is characterized by inflammation and fibrosis. The purinergic P2Y₆ receptor (P2Y₆R) is a pro-inflammatory G_q/G₁₂ family protein-coupled receptor and reportedly contributes to intestinal inflammation and cardiovascular fibrosis, but its role in liver pathogenesis is unknown. Human genomics data analysis revealed that the liver P2Y₆R mRNA expression level is increased during the progression from NAFL to NASH, which positively correlates with inductions of C-C motif chemokine 2 (CCL2) and collagen type I α1 chain (Col1a1) mRNAs. Therefore, we examined the impact of P2Y₆R functional deficiency in mice crossed with a NA

SUBMITTER: Nishiyama K 

PROVIDER: S-EPMC9963899 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature