Distinct replay signatures for prospective decision-making and memory preservation.

ABSTRACT: Theories of neural replay propose that it supports a range of functions, most prominently planning and memory consolidation. Here, we test the hypothesis that distinct signatures of replay in the same task are related to model-based decision-making ("planning") and memory preservation. We designed a reward learning task wherein participants utilized structure knowledge for model-based evaluation, while at the same time had to maintain knowledge of two independent and randomly alternating task environments. Using magnetoencephalography and multivariate analysis, we first identified temporally compressed sequential reactivation, or replay, both prior to choice and following reward feedback. Before choice, prospective replay strength was enhanced for the current task-relevant environment when

SUBMITTER: Wimmer GE 

PROVIDER: S-EPMC9963918 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature