Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.

ABSTRACT: Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA expression in human pancreatic islets have yielded important insights into the molecular drivers of normal islet function and T2D pathophysiology. However, similar studies investigating microRNA (miRNA) expression remain limited. Here, we present data from 63 individuals, the largest sequencing-based analysis of miRNA expression in human islets to date. We characterized the genetic regulation of miRNA expression by decomposing the expression of highly heritable miRNAs into cis- and trans-acting genetic components and mapping cis-acting loci associated

SUBMITTER: Taylor HJ 

PROVIDER: S-EPMC9963967 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature