Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation.

ABSTRACT: Titanium dioxide nanoparticles (TiO₂ NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO₂ NPs using a whole-body inhalation chamber model are rare. In this study, the profile of lymphocyte markers, functional immunoassays, and antioxidant defense markers were analyzed to evaluate the potential adverse effects of seven-week inhalation exposure to two different concentrations of TiO₂ NPs (0.00167 and 0.1308 mg TiO₂/m³) in mice. A dose-dependent effect of TiO₂ NPs on innate immunity was evident in the form of stimulated phagocytic activity of monocytes in low-dose mice and suppressed secre

SUBMITTER: Lehotska Mikusova M 

PROVIDER: S-EPMC9964099 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature