Key Parameters Impacting the Crystal Formation in Antisolvent Membrane-Assisted Crystallization.

ABSTRACT: Antisolvent crystallization is commonly used in the formation of heat-sensitive compounds as it is the case for most active pharmaceutical ingredients. Membranes have the ability to control the antisolvent mass transfer to the reaction medium, providing excellent mixing that inhibits the formation of local supersaturations responsible for the undesired properties of the resulting crystals. Still, optimization of the operating conditions is required. This work investigates the impact of solution velocity, the effect of antisolvent composition, the temperature and gravity, using glycine-water-ethanol as a model crystallization system, and polypropylene flat sheet membranes. Results proved that in any condition, membranes were consistent in providing a narrow crystal size distribution (CSD) w

SUBMITTER: Chergaoui S 

PROVIDER: S-EPMC9964214 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature