Improved DNA Vaccine Delivery with Needle-Free Injection Systems.

ABSTRACT: DNA vaccines have inherent advantages compared to other vaccine types, including safety, rapid design and construction, ease and speed to manufacture, and thermostability. However, a major drawback of candidate DNA vaccines delivered by needle and syringe is the poor immunogenicity associated with inefficient cellular uptake of the DNA. This uptake is essential because the target vaccine antigen is produced within cells and then presented to the immune system. Multiple techniques have been employed to boost the immunogenicity and protective efficacy of DNA vaccines, including physical delivery methods, molecular and traditional adjuvants, and genetic sequence enhancements. Needle-free injection systems (NFIS) are an attractive alternative due to the induction of potent immunogenicity, enha

SUBMITTER: Ledesma-Feliciano C 

PROVIDER: S-EPMC9964240 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature