The Role of Ferroptosis and Cuproptosis in Curcumin against Hepatocellular Carcinoma.

ABSTRACT:

Background

Among cancer-related deaths, hepatocellular carcinoma (HCC) ranks fourth, and traditional Chinese medicine (TCM) treatment is an important complementary alternative therapy for HCC. Curcumin is a natural ingredient extracted from Curcuma longa with anti-HCC activity, while the therapeutic mechanisms of curcumin remain unclear, especially on ferroptosis and cuproptosis.

Methods

Differentially expressed genes (DEGs) of curcumin treatment in PLC, KMCH, and Huh7 cells were identified, respectively. The common genes among them were then obtained to perform functional enrichment analysis and prognostic analysis. Moreover, weighted gene co-expression network analysis (WGCNA) was carried out for the construction of the co-expression network. The ferroptosis potenti

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9964324 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature