Urea Decomposition Mechanism by Dinuclear Nickel Complexes.

ABSTRACT: Urease is an enzyme containing a dinuclear nickel active center responsible for the hydrolysis of urea into carbon dioxide and ammonia. Interestingly, inorganic models of urease are unable to mimic its mechanism despite their similarities to the enzyme active site. The reason behind the discrepancy in urea decomposition mechanisms between inorganic models and urease is still unknown. To evaluate this factor, we synthesized two bis-nickel complexes, [Ni₂L(OAc)] (1) and [Ni₂L(Cl)(Et₃N)₂] (2), based on the Trost bis-Pro-Phenol ligand (L) and encompassing different ligand labilities with coordination geometries similar to the active site of jack bean urease. Both mimetic complexes produced ammonia from urea, (1) and (2), were ten- and f

SUBMITTER: Martins CO 

PROVIDER: S-EPMC9964345 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature