Ontology highlight
ABSTRACT:
SUBMITTER: Costa CMX
PROVIDER: S-EPMC9964390 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Pharmaceuticals (Basel, Switzerland) 20230130 2
Targeted antitumour therapy has revolutionized the treatment of several types of tumours. Among the validated targets, phosphatidylinositol-3 kinase (PI3K) deserves to be highlighted. Several PI3K inhibitors have been developed for the treatment of cancer, including gedatolisib (<b>4</b>). This inhibitor was elected as a prototype and molecular modifications were planned to design a new series of simplified gedatolisib analogues (<b>5a-f</b>). The analogues were synthesised, and the comparative ...[more]