A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line.

ABSTRACT: A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt₂Put₂(NH₃)₄]Cl₄) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt₂Put₂(NH₃)₄]Cl₄ was evidenced on cellular protei

SUBMITTER: Silva JD 

PROVIDER: S-EPMC9964417 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature