Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis.

ABSTRACT: Glioblastoma (GBM) is one of the most aggressive forms of cancer. Although IDH1 mutation indicates a good prognosis and a potential target for treatment, most GBMs are IDH1 wild-type. Identifying additional molecular markers would help to generate personalized therapies and improve patient outcomes. Here, we used our recently developed metabolic modeling method (genome-wide precision metabolic modeling, GPMM) to investigate the metabolic profiles of GBM, aiming to identify additional novel molecular markers for this disease. We systematically analyzed the metabolic reaction profiles of 149 GBM samples lacking IDH1 mutation. Forty-eight reactions showing significant association with prognosis were identified. Further analysis indicated that the purine recycling, nucleotide interconversion,

SUBMITTER: Shen Q 

PROVIDER: S-EPMC9964559 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature