Taurine and Creatine Transporters as Potential Drug Targets in Cancer Therapy.

ABSTRACT: Cancer cells are characterized by uncontrolled growth, proliferation, and impaired apoptosis. Tumour progression could be related to poor prognosis and due to this fact, researchers have been working on novel therapeutic strategies and antineoplastic agents. It is known that altered expression and function of solute carrier proteins from the SLC6 family could be associated with severe diseases, including cancers. These proteins were noticed to play important physiological roles through transferring nutrient amino acids, osmolytes, neurotransmitters, and ions, and many of them are necessary for survival of the cells. Herein, we present the potential role of taurine (SLC6A6) and creatine (SLC6A8) transporters in cancer development as well as therapeutic potential of their inhibitors. Experim

SUBMITTER: Stary D 

PROVIDER: S-EPMC9964810 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature