Impact of Pollutant Ozone on the Biophysical Properties of Tear Film Lipid Layer Model Membranes.

ABSTRACT: Ozone exposure from environmental smog has been implicated as a risk factor for developing dry eye disease (DED). The tear film lipid layer (TFLL), which is the outermost layer of the tear film and responsible for surface tension reduction while blinking, is in direct contact with the environment and serves as the first line of defense against external aggressors such as environmental pollution. The impact of exposure to ozone on the biophysical properties of three TFLL model membranes was investigated. These model membranes include a binary mixture of cholesteryl oleate (CO) and L-α-phosphatidylcholine (egg PC), a ternary mixture of CO, glyceryl trioleate (GT) and PC, as well as a quaternary mixture of CO, GT, a mixture of free fatty acids palmitic acid and stearic acid (FFAs) and PC. Bio

SUBMITTER: Keramatnejad M 

PROVIDER: S-EPMC9964828 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature