Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting.

ABSTRACT: Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of drugs to the brain at pharmacologically relevant concentrations, bypassing the blood-brain barrier (BBB) and minimizing adverse side effects. IN drug delivery can be particularly promising for the treatment of neurodegenerative diseases. The drug delivery mechanism involves the initial drug penetration through the nasal epithelial barrier, followed by drug diffusion in the perivascular or perineural spaces along the olfactory or trigeminal nerves, and final extracellular diffusion throughout the brain. A part of the drug may be lost by drainage through the lymphatic system, while a part may even enter the systemic circulation and reach the brain by crossing the BBB. Alternatively, drugs can be dir

SUBMITTER: Marcello E 

PROVIDER: S-EPMC9964911 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature