Inflammatory Immune Process and Depression-like Behavior in Hypothyroid Rats: A [¹⁸F] DPA-714 Micro Positron Emission Tomography Study.

ABSTRACT: Hypothyroidism is closely related to mental disorders, mainly depression, through an as-yet-unknown mechanism. The cerebral inflammatory immune process has been implied to play a pivotal role in the onset of affective symptoms in several conditions. In order to gain insight into the mechanism underlying the depressive behaviors in hypothyroid rats, brain microglial activation was evaluated using micro positron emission tomography imaging with a translocator protein (TSPO) radioligand. Hypothyroidism was induced in adult male Wistar rats by administration of 0.05% propylthiouracil in drinking water for five weeks. Open field, forced swimming and tail suspension tests were employed to evaluate the depressive behavior in hypothyroid rats, and the relationship between the behavioral changes an

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9964991 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature