Effect of Copolymer Properties on the Phase Behavior of Ibuprofen-PLA/PLGA Mixtures.

ABSTRACT: Prediction of compatibility of the active pharmaceutical ingredient (API) with the polymeric carrier plays an essential role in designing drug delivery systems and estimating their long-term physical stability. A key element in deducing API-polymer compatibility is knowledge of a complete phase diagram, i.e., the solubility of crystalline API in polymer and mutual miscibility of API and polymer. In this work, the phase behavior of ibuprofen (IBU) with different grades of poly(D,L-lactide-co-glycolide) (PLGA) and polylactide (PLA), varying in composition of PLGA and molecular weight of PLGA and PLA, was investigated experimentally using calorimetry and computationally by the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state (EOS). The phase diagrams constructe

SUBMITTER: Iemtsev A 

PROVIDER: S-EPMC9965113 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature