Binding of Different Cyclosporin Variants to Micelles Evidenced by NMR and MD Simulations.

ABSTRACT: Peptides play a critical role in the life of organisms, performing completely different functions. The biological activity of some peptides, such as cyclosporins, can be determined by the degree of membrane permeability. Thus, it becomes important to study how the molecule interacts with lipid bilayers. Cyclosporins C, E, H and L were characterised molecular dynamics simulation; NMR spectroscopy studies were also carried out for cyclosporins C and E. The comparison of one- and two-dimensional spectra revealed certain similarities between spatial structures of the studied cyclosporin variants. Upon dissolving in water containing DPC micelles, which serve as model membranes, subtle changes in the NMR spectra appear, but in a different way for different cyclosporins. In order to understand wh

SUBMITTER: Kobchikova PP 

PROVIDER: S-EPMC9965255 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature