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Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story.

ABSTRACT: Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapies promoted the idea that activation of alternative signaling pathways is effective in reducing the risk of atherosclerosis and heart failure. Gut-derived molecules, gut hormones, and gut microbiota metabolites showed both positive and detrimental effects in cardiometabolic disorders. Although inflammation plays a key role in cardiometabolic disorders, additional intracellular signaling pathways are involved and could explain the observed effects. Revealing the involved molecular mechanisms could provide novel therapeutic strategies and a better understanding of the relationship between the gut, metabolic syndrome, and cardiovascular diseases.

SUBMITTER: Inceu AI

PROVIDER: S-EPMC9965280 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story.

Inceu Andreea-Ioana AI Neag Maria-Adriana MA Craciun Anca-Elena AE Buzoianu Anca-Dana AD

International journal of molecular sciences 20230208 4

Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapies promoted the idea that activation of alternative signaling pathways is effective in reducing the risk of atherosclerosis and heart failure. Gut-derived molecules, gut hormones, and gut microbiota m ...[more]

PMID: 36834796

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