Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrP^Sc Profile.

ABSTRACT: Bovine spongiform encephalopathy (BSE) belongs to the group of transmissible spongiform encephalopathies and is associated with the accumulation of a pathological isoform of the host-encoded glycoprotein, designated prion protein (PrP^Sc). Classical BSE (C-type) and two atypical BSE forms (L- and H-type) are known, and can be discriminated by biochemical characteristics. The goal of our study was to identify type-specific PrP^Sc profiles by using Immunohistochemistry. In our study, brain samples from 21 cattle, intracerebrally inoculated with C-, H-, and L-type BSE, were used. In addition, the corresponding samples from three orally C-type BSE infected animals were also included. From all animals, a lesion and PrP^Sc-profiles of six brain regions were determin

SUBMITTER: Fast C 

PROVIDER: S-EPMC9965285 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature