Current Challenges and Opportunities of Photodynamic Therapy against Cancer.

ABSTRACT:

Background

Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption of the tumor area. Moreover, PDT can result in damage to the tumor vasculature and induce the release and/or exposure of damage-associated molecular patterns (DAMPs) that may initiate an antitumor immune response. However, there are currently several challenges of PDT that limit its widespread application for certain indications in the clinic.

Methods

A literature study was conducted to comprehensively discuss these challenges and to identify opportunities for improvement.

Results

The most notable challenges of PDT and opportunities to improve them ha

SUBMITTER: Huis In 't Veld RV 

PROVIDER: S-EPMC9965442 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature