Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin.

ABSTRACT: The oral delivery system is very important and plays a significant role in increasing the solubility of drugs, which eventually will increase their absorption by the digestive system and enhance the drug bioactivity. This study was conducted to synthesize a novel curcumin nano lipid carrier (NLC) and use it as a drug carrier with the help of computational molecular docking to investigate its solubility in different solid and liquid lipids to choose the optimum lipids candidate for the NLCs formulation and avoid the ordinary methods that consume more time, materials, cost, and efforts during laboratory experiments. The antiviral activity of the formed curcumin-NLC against SARS-CoV-2 (COVID-19) was assessed through a molecular docking study of curcumin's affinity towards the host cell recept

SUBMITTER: Albasri OWA 

PROVIDER: S-EPMC9965590 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature