Yeast-Based Virus-like Particles as an Emerging Platform for Vaccine Development and Delivery.

ABSTRACT: Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating epitopes, make them an ideal platform for vaccine development and drug delivery. Commercial use of Gardasil-9 and Cervarix showed the usefulness of VLPs in vaccine formulation. Further, chimeric VLPs allow the raising of an immune response against different immunogens and thereby can help reduce the generation of medical or clinical waste. The economically viable production of VLPs significantly impacts their usage, application, and availability. To this end, several hosts have been used and tested. The present review will discuss VLPs produced using different yeasts as fermentation hosts. We also compile a l

SUBMITTER: Srivastava V 

PROVIDER: S-EPMC9965603 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature