Evaluation of Epithelial-Mesenchymal Transition Markers in Autoimmune Thyroid Diseases.

ABSTRACT: A state of chronic inflammation is common in organs affected by autoimmune disorders, such as autoimmune thyroid diseases (AITD). Epithelial cells, such as thyroid follicular cells (TFCs), can experience a total or partial transition to a mesenchymal phenotype under these conditions. One of the major cytokines involved in this phenomenon is transforming growth factor beta (TGF-β), which, at the initial stages of autoimmune disorders, plays an immunosuppressive role. However, at chronic stages, TGF- β contributes to fibrosis and/or transition to mesenchymal phenotypes. The importance of primary cilia (PC) has grown in recent decades as they have been shown to play a key role in cell signaling and maintaining cell structure and function as mechanoreceptors. Deficiencies of PC can trigger epi

SUBMITTER: Sacristan-Gomez P 

PROVIDER: S-EPMC9965822 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature