Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo.

ABSTRACT:

Background

Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against mucormycetes.

Methods

Rhizopus arrhizus (Ra), Rhizopus microsporus (Rm), Lichtheimia ramosa (Lr), Lichtheimia corymbifera (Lc), Rhizomucor pusillus (Rmp), and Mucor circinelloides (Mc) spores were opsonized with human and mouse serum, and C1q, C3c, and terminal complement complex (C5b-9) deposition was measured. Additionally, thrombocytopenic, C3-deficient, or C6-deficient mice were intravenously infected with selected isolates. Survival and i

SUBMITTER: Harpf V 

PROVIDER: S-EPMC9965864 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature