Paths of Evolution of Progressive Anaplastic Meningiomas: A Clinical and Molecular Pathology Study.

ABSTRACT: Grade 3 meningiomas are rare malignant tumors that can originate de novo or from the progression of lower grade meningiomas. The molecular bases of anaplasia and progression are poorly known. We aimed to report an institutional series of grade 3 anaplastic meningiomas and to investigate the evolution of molecular profile in progressive cases. Clinical data and pathologic samples were retrospectively collected. VEGF, EGFR, EGFRvIII, PD-L1; and Sox2 expression; MGMT methylation status; and TERT promoter mutation were assessed in paired meningioma samples collected from the same patient before and after progression using immunohistochemistry and PCR. Young age, de novo cases, origin from grade 2 in progressive cases, good clinical status, and unilateral side, were associated wit

SUBMITTER: Di Bonaventura R 

PROVIDER: S-EPMC9965923 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature