Proteome-Wide Screening of Potential Vaccine Targets against Brucella melitensis.

ABSTRACT: The ongoing antibiotic-resistance crisis is becoming a global problem affecting public health. Urgent efforts are required to design novel therapeutics against pathogenic bacterial species. Brucella melitensis is an etiological agent of brucellosis, which mostly affects sheep and goats but several cases have also been reported in cattle, water buffalo, yaks and dogs. Infected animals also represent the major source of infection for humans. Development of safer and effective vaccines for brucellosis remains a priority to support disease control and eradication in animals and to prevent infection to humans. In this research study, we designed an in-silico multi-epitopes vaccine for B. melitensis using computational approaches. The pathogen core proteome was screened for good va

SUBMITTER: Malik M 

PROVIDER: S-EPMC9966016 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature