Drugging Hijacked Kinase Pathways in Pediatric Oncology: Opportunities and Current Scenario.

ABSTRACT: Childhood cancer is considered rare, corresponding to ~3% of all malignant neoplasms in the human population. The World Health Organization (WHO) reports a universal occurrence of more than 15 cases per 100,000 inhabitants around the globe, and despite improvements in diagnosis, treatment and supportive care, one child dies of cancer every 3 min. Consequently, more efficient, selective and affordable therapeutics are still needed in order to improve outcomes and avoid long-term sequelae. Alterations in kinases' functionality is a trademark of cancer and the concept of exploiting them as drug targets has burgeoned in academia and in the pharmaceutical industry of the 21st century. Consequently, an increasing plethora of inhibitors has emerged. In the present study, the expression patterns o

SUBMITTER: Candido MF 

PROVIDER: S-EPMC9966033 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature