Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives.

ABSTRACT: Herein, we describe the synthesis and evaluation of anti-inflammatory activities of new curcumin derivatives. The thirteen curcumin derivatives were synthesized by Steglich esterification on one or both of the phenolic rings of curcumin with the aim of providing improved anti-inflammatory activity. Monofunctionalized compounds showed better bioactivity than the difunctionalized derivatives in terms of inhibiting IL-6 production, and known compound 2 presented the highest activity. Additionally, this compound showed strong activity against PGE₂. Structure-activity relationship studies were carried out for both IL-6 and PGE₂, and it was found that the activity of this series of compounds increases when a free hydroxyl group or aromatic ligands are present on the

SUBMITTER: Gonzalez Y 

PROVIDER: S-EPMC9966181 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature