Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds.

ABSTRACT: Augmenting the vascular supply to generate new tissues, a crucial aspect in regenerative medicine, has been challenging. Recently, our group showed that calcium phosphate can induce the formation of a functional neo-angiosome without the need for microsurgical arterial anastomosis. This was a preclinical proof of concept for biomaterial-induced luminal sprouting of large-diameter vessels. In this study, we investigated if sprouting was a general response to surgical injury or placement of an inorganic construct around the vessel. Cylindrical biocement scaffolds of differing chemistries were placed around the femoral vein. A contrast agent was used to visualize vessel ingrowth into the scaffolds. Cell populations in the scaffold were mapped using immunohistochemistry. Calcium phosphate scaf

SUBMITTER: Ouhaddi Y 

PROVIDER: S-EPMC9966587 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature