Metformin-NSAIDs Molecular Salts: A Path towards Enhanced Oral Bioavailability and Stability.

ABSTRACT: According to the World Health Organization, more than 422 million people worldwide have diabetes. The most common oral treatment for type 2 diabetes is the drug metformin (MTF), which is usually formulated as a hydrochloride to achieve higher water solubility. However, this drug is also highly hygroscopic, thus showing stability problems. Another kind of worldwide prescribed drug is the non-steroidal anti-inflammatory drug (NSAID). These latter, on the contrary, show a low solubility profile; therefore, they must be administered at high doses, which increases the probability of secondary effects. In this work, novel drug-drug pharmaceutical solids combining MTF-NSAIDs have been synthesized in solution or by mechanochemical methods. The aim of this concomitant treatment is to improve the ph

SUBMITTER: Acebedo-Martinez FJ 

PROVIDER: S-EPMC9966766 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature