ABCG5 and ABCG8 Are Involved in Vitamin K Transport.

ABSTRACT: ATP-binding cassette protein G5 (ABCG5)/ABCG8 heterodimer exports cholesterol from cells, while Niemann-Pick C1-like 1 (NPC1L1) imports cholesterol and vitamin K. We examined whether ABCG5/ABCG8 transports vitamin K similar to NPC1L1. Since high concentrations of vitamin K₃ show cytotoxicity, the cytoprotective effects of ABCG5/ABCG8 were examined. BHK cells expressing ABCG5/ABCG8 were more resistant to vitamin K₃ cytotoxicity than control cells, suggesting that ABCG5/ABCG8 transports vitamin K₃ out of cells. The addition of vitamin K₁ reversed the effects of ABCG5/ABCG8, suggesting that vitamin K₁ competitively inhibits the transport of vitamin K₃. To examine the transport of vitamin K₁ by ABCG5/ABCG8, vitamin K<

SUBMITTER: Matsuo M 

PROVIDER: S-EPMC9966996 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature